Using State Variables to Model the Response of Tumour Cells to Radiation and Heat: A Novel Multi-Hit-Repair Approach
Fit of experimental data (redrawn) from Sapareto et al. . Chinese hamster cells were irradiated with 5 Gy prior (negative time gap) or after heat (positive time gap). Heat (HT) is applied during 40 min (±20 min of point 0 on the time gap axis). Temperature during heating was 42.5°C. Heat specific parameter values are given in Table 3. Radiation specific parameter values: solid line (optimized) Gy−1, h−1, h−1, Gy−1, Gy−1; dotted line (not optimized) Gy−1, h−1, h−1, Gy−1, Gy−1; dashed line (optimized without baseline points) Gy−1, h−1, h−1, Gy−1, Gy−1.