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Computational and Mathematical Methods in Medicine
Volume 2013, Article ID 617604, 12 pages
Research Article

Normality Index of Ventricular Contraction Based on a Statistical Model from FADS

1Nuclear Cardiology Department, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1 Colonia Seccion XVI, Tlalpan, 14080 Mexico City, DF, Mexico
2Neuroimaging Laboratory, Electrical Engineering Department, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco No. 186 Colonia Vicentina, Iztapalapa, 09340 Mexico City, DF, Mexico

Received 27 September 2012; Accepted 22 February 2013

Academic Editor: Angel García-Crespo

Copyright © 2013 Luis Jiménez-Ángeles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Radionuclide-based imaging is an alternative to evaluate ventricular function and synchrony and may be used as a tool for the identification of patients that could benefit from cardiac resynchronization therapy (CRT). In a previous work, we used Factor Analysis of Dynamic Structures (FADS) to analyze the contribution and spatial distribution of the 3 most significant factors (3-MSF) present in a dynamic series of equilibrium radionuclide angiography images. In this work, a probability density function model of the 3-MSF extracted from FADS for a control group is presented; also an index, based on the likelihood between the control group's contraction model and a sample of normal subjects is proposed. This normality index was compared with those computed for two cardiopathic populations, satisfying the clinical criteria to be considered as candidates for a CRT. The proposed normality index provides a measure, consistent with the phase analysis currently used in clinical environment, sensitive enough to show contraction differences between normal and abnormal groups, which suggests that it can be related to the degree of severity in the ventricular contraction dyssynchrony, and therefore shows promise as a follow-up procedure for patients under CRT.