Influence of Distal Resistance and Proximal Stiffness on Hemodynamics and RV Afterload in Progression and Treatments of Pulmonary Hypertension: A Computational Study with Validation Using Animal Models
Table 1
Parameters from experimental measurements to develop and validate numerical models, 8 in control and 9 in hypertensive condition. Mean ± SD performed for each condition (arterial wall thickness, elastic modulus, PVR, and mPAP) and all cases (diameter, CO, and HR).
No.
Thickness (mm)
Elastic modulus (kPa)
PVR (mm Hg/(L/min))
mPAP (mm Hg)
Diameter (mm)
CO (L/min)
HR (Beat/min)
Control
165
3.68
72.7
4.91
18.5
16.0
3.88
114
166
3.44
136
4.79
29.0
19.7
6.06
147
174
3.04
138
8.88
41.0
18.2
4.62
130
175
2.94
105
5.17
30.0
21.8
5.80
113
176
3.34
98.4
3.83
17.5
19.8
4.70
100
177
3.71
64.1
5.01
18.7
19.7
3.80
94
180
3.34
77.2
3.64
17.7
19.9
5.22
114
181
3.52
86.0
3.08
18.0
18.9
5.85
113
Mean ± SD
Hyper
167
4.19
185
14.3
68.0
24
3.45
125
168
3.50
113
19.7
39.0
18.75
5.21
118
169
5.12
92.6
7.48
67.0
20.4
5.12
135
170
3.60
116
13.1
51.0
20.46
4.12
122
171
3.98
252
12.4
65.0
22.55
3.87
131
172
3.84
267
16.8
94.0
19.94
5.36
148
173
3.42
187
17.5
67.0
18.8
3.52
139
178
3.90
245
19.0
81.0
20.65
5.20
117
179
3.97
136
15.6
33.4
22.22
4.83
132
Mean ± SD
The averaged value for all control and hypertensive cases.
