Influence of Distal Resistance and Proximal Stiffness on Hemodynamics and RV Afterload in Progression and Treatments of Pulmonary Hypertension: A Computational Study with Validation Using Animal Models

Table 3

Proposed treatments on PAH with vasodilation and proximal vascular remodeling (each proposed treatment targeted to reduce one parameter from previous stage).

Hypertensive	All parameters from hypertensive state (Table 1)
Vasodilation	PVR: 15.1 → 4.91 mm Hg/(L/min)
Lower EM	EM: 177 → 97.1 kPa
Lower h	h: 3.95 → 3.38 mm