Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

<table>Drug-specific multiobjective optimisation. Top and bottom panels illustrate the optimised model (solid traces) overlaid with experimental AP data (dashed traces) of peripheral sinoatrial node (pSAN) APs under control conditions (a) and in the presence of 0.1 <i>μ</i>M E-4031, a selective blocker of <svg height="15.3375" id="M533" style="vertical-align:-3.27605pt" version="1.1" viewbox="0 0 17.725 15.3375" width="17.725" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> channels (b). </table>

Computational and Mathematical Methods in Medicine

fig6

Figure 6

Figure 6: Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity 