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Computational and Mathematical Methods in Medicine
Volume 2013, Article ID 730374, 9 pages
http://dx.doi.org/10.1155/2013/730374
Research Article

Information Analysis on Neural Tuning in Dorsal Premotor Cortex for Reaching and Grasping

1Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China
2Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
3Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, China

Received 19 January 2013; Revised 1 May 2013; Accepted 13 May 2013

Academic Editor: Lei Ding

Copyright © 2013 Yan Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Previous studies have shown that the dorsal premotor cortex (PMd) neurons are relevant to reaching as well as grasping. In order to investigate their specific contribution to reaching and grasping, respectively, we design two experimental paradigms to separate these two factors. Two monkeys are instructed to reach in four directions but grasp the same object and grasp four different objects but reach in the same direction. Activities of the neuron ensemble in PMd of the two monkeys are collected while performing the tasks. Mutual information (MI) is carried out to quantitatively evaluate the neurons’ tuning property in both tasks. We find that there exist neurons in PMd that are tuned only to reaching, tuned only to grasping, and tuned to both tasks. When applied with a support vector machine (SVM), the movement decoding accuracy by the tuned neuron subset in either task is quite close to the performance by full ensemble. Furthermore, the decoding performance improves significantly by adding the neurons tuned to both tasks into the neurons tuned to one property only. These results quantitatively distinguish the diversity of the neurons tuned to reaching and grasping in the PMd area and verify their corresponding contributions to BMI decoding.