Epitope Mapping of Metuximab on CD147 Using Phage Display and Molecular Docking

Table 1

Templates used in modeling metuximab.

Region*	PDB	Identity	Align length	Mismatches	Gap openings	𝐸 value
HFR	1SBS	95.52	67	3	0	0.00𝐸+00
LFR	1IAI	85.48	62	9	0	3.00𝐸−22
H1	2DLF	100	10	0	0	1.00𝐸−07
H2	2DLF	75	20	3	2	3.00𝐸−08
H3	1A0Q	0	0	0	0	0.00𝐸+00
L1	1QNZ	100	6	0	0	5.80𝐸−02
L2	3FCT	83.33	6	1	0	3.30𝐸−01
L3	1NCD	77.78	9	2	0	5.00𝐸−03

∗HFR: heavy chain framework region; LFR: light chain framework region; H1, H2, H3, L1, L2, and L3 refer to CDR1, CDR2, and CDR3 loops of heavy and light chain, respectively.