Computational and Mathematical Methods in Medicine / 2013 / Article / Tab 3

Research Article

Understanding the Pathogenesis of Kawasaki Disease by Network and Pathway Analysis

Table 3

Pathways analyzed by GeneGo Meta core.

Pathway categoriesPathwaysFunctionsEnrichment genes

Immune response(1) HSP60 and HSP70/TLR signaling pathway
(2) Inflammasome in inflammatory response
(3) NF-AT signaling and leukocyte interactions
(4) Role of HMGB1 in dendritic cell maturation and migration
(5) Histamine signaling in dendritic cells
(6) CD16 signaling in NK cells
(7) MIF in innate immunity response
(8) Th1 and Th2 cell differentiation
(9) HMGB1 release from the cell
(10) PGE2 signaling in immune response
(11) Histamine H1 receptor signaling in immune response
(12) Role of DAP12 receptors in NK cells
Pro-inflammatory response and anti-inflammatory response; cellular and humoral immune response; NO production; apoptosis and antiapoptosis; secretion of leukotrienes and prostaglandins; proliferation and differentiation of eosinophils; chemotaxis; proliferation, differentiation, activation of T cell; cell necrosis; smooth muscle construction; vascular permeability; blood coagulation; cytoskeleton remodelingCD14, HSP70, IL-10, TNF-α, IL-1β, CD40, MHC class I, IL-4, NOD1, CARD7, IL-18, TNF-R1, CD40L, IP3receptor, CCL5, HLA-E, PLA2, MIF, CCR5, MMP13, HLA-C, HLA-B, HLA-G, HLA-E, Stromelysin-1

Cell adhesionPlasmin signaling
ECM remodeling
Fibrinolysis; cell viabilityTGF-β 2,VEGF-A, TGF-β receptor type 2, VEGFR-2, Fibrinogen, MMP-13, TIMP2, Stromelysin-1, MMP-13, MMP-12

Development(1) Cross-talk between VEGF and Angiopoietin 1 signaling pathways
(2) Regulation of epithelial-to-mesenchymal transition (EMT)
(3) TGF-β-dependent induction of EMT via SMADs
(4) PEDF signaling
(5) Glucocorticoid receptor signaling
Leukocyte-endothelial adhesion; epithelial-to-mesenchymal transition; proteasomal degradation; inhibition of angiogenesis; immune responseVEGF-A, VEGFR-2, Angiopoietin 1, IP3 receptor, TGF-β 2, IL-1β, TNF-α, TNF-R1, TGF-β receptor type 2, SMAD3, TGF-β, HSP70, MMP13

Apoptosis and survival(1) Role of IAP-proteins in apoptosis
(2) Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Caspase dependent and independent apoptosis; apoptosis and antiapoptosisTNF-α, TNF-R1, HSP70, caspase3, CD40L, CD40

TranscriptionNF-kB signaling pathwayActivate the transcription of target genesTNF-α, TGF-β, TNF-R1, CD14

FDR = 0.01.