| | Pathway categories | Pathways | Functions | Enrichment genes |
| | Immune response | (1) HSP60 and HSP70/TLR signaling pathway
(2) Inflammasome in inflammatory response
(3) NF-AT signaling and leukocyte interactions
(4) Role of HMGB1 in dendritic cell maturation and migration
(5) Histamine signaling in dendritic cells
(6) CD16 signaling in NK cells
(7) MIF in innate immunity response
(8) Th1 and Th2 cell differentiation
(9) HMGB1 release from the cell
(10) PGE2 signaling in immune response
(11) Histamine H1 receptor signaling in immune response
(12) Role of DAP12 receptors in NK cells | Pro-inflammatory response and anti-inflammatory response; cellular and humoral immune response; NO production; apoptosis and antiapoptosis; secretion of leukotrienes and prostaglandins; proliferation and differentiation of eosinophils; chemotaxis; proliferation, differentiation, activation of T cell; cell necrosis; smooth muscle construction; vascular permeability; blood coagulation; cytoskeleton remodeling | CD14, HSP70, IL-10, TNF-α, IL-1β, CD40, MHC class I, IL-4, NOD1, CARD7, IL-18, TNF-R1, CD40L, IP3receptor, CCL5, HLA-E, PLA2, MIF, CCR5, MMP13, HLA-C, HLA-B, HLA-G, HLA-E, Stromelysin-1 |
| | Cell adhesion | Plasmin signaling
ECM remodeling | Fibrinolysis; cell viability | TGF-β 2,VEGF-A, TGF-β receptor type 2, VEGFR-2, Fibrinogen, MMP-13, TIMP2, Stromelysin-1, MMP-13, MMP-12 |
| | Development | (1) Cross-talk between VEGF and Angiopoietin 1 signaling pathways
(2) Regulation of epithelial-to-mesenchymal transition (EMT)
(3) TGF-β-dependent induction of EMT via SMADs
(4) PEDF signaling
(5) Glucocorticoid receptor signaling | Leukocyte-endothelial adhesion; epithelial-to-mesenchymal transition; proteasomal degradation; inhibition of angiogenesis; immune response | VEGF-A, VEGFR-2, Angiopoietin 1, IP3 receptor, TGF-β 2, IL-1β, TNF-α, TNF-R1, TGF-β receptor type 2, SMAD3, TGF-β, HSP70, MMP13 |
| | Apoptosis and survival | (1) Role of IAP-proteins in apoptosis
(2) Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway | Caspase dependent and independent apoptosis; apoptosis and antiapoptosis | TNF-α, TNF-R1, HSP70, caspase3, CD40L, CD40 |
| | Transcription | NF-kB signaling pathway | Activate the transcription of target genes | TNF-α, TGF-β, TNF-R1, CD14 |
|
|
