Dynamics of Posttranslational Modifications of p53

Figure 1

Schematic depiction of the model for the p53 networks in response to DNA damage. Transcription regulation is denoted in thick line. Degradation is denoted in dotted line. Sharp and blunt arrow denote activation and suppression, respectively. ATM’s catalyzing phosphorylation of Mdm2, allowing Mdm2 easier to degrade, is regarded as repressive.