Designing Lead Optimisation of MMP-12 Inhibitors

Figure 7

Evolution of the proportion of the best compounds found by the optimisation designs in the 𝛼=0.01 optimality region (a) and 𝛼=0.05 optimality region (b). The EDO design is represented by the blue line and the GAO by the green line.

(a) [𝛼=0.01]

(b) [𝛼=0.05]