Modeling and Visualizing Cell Type Switching

Table 1

Summary of different kinds of cell type transitions with possible examples from myeloid differentiation tree shown in Figure 1.

Transition	Example	Definition
Spontaneous-differentiation	CMP to MEP	Cell switches to a more specialized state
Spontaneous-dedifferentiation	MON to GMP	Cell reverts to an earlier multipotent state
Off-differentiation	GMP to ERY	Cell switches to a more specialized state but on a wrong branch of the lineage tree
Off-dedifferentiation	MEG to GMP	Differentiated cell reverts to an earlier multipotent state but on a wrong branch of the lineage tree
Transdifferentiation	GRA to ERY	Differentiated cell switches to another differentiated state