Modeling and Visualizing Cell Type Switching

Table 2

Cell type transitions discovered and visualized in the myeloid differentiation network shown Figure 3 and in mutationally altered forms of this network.

Figure	Network	Cell type switch	Kind
Figure 4(a)	Wild type	CMP ⇒ MON	Spontaneous-differentiation
		MEP ⇒ GMP	Off-differentiation
		MEG ⇔ CMP	High separation
		MEP ⇒ GMP	Off-differentiation
		MEP ⇔ MEG	Low separation
Figure 4(b)	EgrNab/Gfi-1	CMP ⇒ MEG	Spontaneous-differentiation
		ERY ⇒ GRA	Transdifferentiation
		GRA ⇔ CMP	Low separation
Figure 4(c)	Fli-1/EKLF	MEG ⇒ CMP	Spontaneous-dedifferentiation
		MEG ⇒ MON	Transdifferentiation
		MEG ⇒ GMP	Off-differentiation
		MEG ⇔ MON	Low separation
		GMP ⇔ MON	High separation
Figure 5(b)	GATA-2/PU.1	GRA ⇒ CMP	Spontaneous-dedifferentiation
		MEP ⇒ MON	Off-differentiation
		GMP ⇒ ERY	Off-differentiation
		GMP ⇒ MEG	Off-differentiation
Figure 5(c)	GATA-1/PU.1	MON ⇒ GMP	Transdifferentiation