Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/cmmm/volume-2014/360179/figures/360179.fig.008a.svgz" name="360179.fig.008a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Laplace-based model</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/cmmm/volume-2014/360179/figures/360179.fig.008b.svgz" name="360179.fig.008b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>Multiscale model; <svg height="8.91176pt" id="M137" style="vertical-align:-0.2130003pt" version="1.1" viewbox="-0.0498162 -8.69876 26.817 8.91176" width="26.817pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z" id="g113-117"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="341" vert-adv-y="341"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,8.405,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,20.143,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> ms</td></tr></table>

<div>Electric potential (<svg height="9.04777pt" id="M134" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -8.99795 10.3533 9.04777" width="10.3533pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M488 658H270V630C328 626 335 619 335 579C217 574 44 509 44 330C44 147 221 88 335 86C335 38 328 32 265 28V0H488V28C425 32 418 38 418 86C534 88 710 153 710 337C710 517 538 575 418 579C418 619 425 626 488 630V658ZM335 118C249 124 136 180 136 337C136 490 251 543 335 547V118ZM418 547C502 543 618 491 618 333S503 124 418 118V547Z" id="g113-150"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="754" vert-adv-y="754"></glyph.data></g></svg>) results for the second tDCS electrode configuration: anode at (<svg height="10.3396pt" id="M135" style="vertical-align:-1.64084pt" version="1.1" viewbox="-0.0498162 -8.69876 58.82 10.3396" width="58.82pt" xmlns="http://www.w3.org/2000/svg" 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id="g113-56"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,42.421,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,48.924,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,52.013,0)"><path d="M447 623H65C61 580 56 530 47 475H76C100 541 106 550 172 550H388C308 376 196 170 91 -1L98 -12L172 -2C268 204 360 408 455 611L447 623Z" id="g113-56"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>) and cathode at (<svg height="10.3396pt" id="M136" style="vertical-align:-1.64084pt" version="1.1" viewbox="-0.0498162 -8.69876 39.5638 10.3396" width="39.5638pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,6.503,0)"><path d="M95 130C70 130 46 113 46 88C46 72 54 64 59 64C93 55 121 33 121 -3C121 -41 93 -68 44 -88L55 -117C117 -98 186 -56 186 22C186 91 131 130 95 130Z" id="g113-45"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,11.863,0)"><path d="M535 230V280H52V230H535Z" id="g117-33"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,19.816,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,26.319,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,32.822,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 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Computational and Mathematical Methods in Medicine

fig8

Figure 8

Figure 8: Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization 

Figure 8 | Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization 