Identification of Crucial Parameters in a Mathematical Multiscale Model of Glioblastoma Growth

Figure 2

General model setup. The scheme shows how the different scales are combined. From the cellular grid on which the model is described by an ABM and a PDE, information about the local glucose concentration is transferred to each individual cell. Each cell is equipped with a system of ODEs describing the molecular interaction network. After simulating this system of ODEs, the cell’s phenotype (migrating, proliferating, or quiescent) is determined. This phenotype then decides on the action of each individual cell on the cellular scale (i.e., the phenotype is realized on the grid).