Identification of Crucial Parameters in a Mathematical Multiscale Model of Glioblastoma Growth
Figure 4
The sensitivity coefficients for parameter for the tested factors in the interval for all four tested initial glucose levels 3 × 10−1 gL−1, 1.125 gL−1, 2.25 gL−1, and 4.5 gL−1. (a) The sensitivity coefficients for the number of time steps necessary for the first cell to reach the boundary, (b) the sensitivity coefficients for the total number of cells in this last time step, (c) the sensitivity coefficients for the number of migrating cells, and (d) the sensitivity coefficient for the number of proliferating cells, respectively. Each marker represents the mean result of three simulations with the same parameter scaling with the same initial level of glucose. In all these figures, the black crosses (×) represent the data for an initial glucose level of 3 × 10−1 gL−1, the blue circles (●) for an initial glucose concentration of 1.125 gL−1, and the red diamond (◆) and the yellow plus sign (+) for an initial glucose level of 2.25 gL−1 and 4.5 gL−1, respectively.
