Modeling the Relationship between Fluorodeoxyglucose Uptake and Tumor Radioresistance as a Function of the Tumor Microenvironment
Figure 1
Cartoon of the microenvironment with respect to the blood supply. Due to a limited blood supply, there are limited supplies of the oxygen and the key nutrient, glucose. Cells with adequate oxygen and glucose are actively proliferating, while cells distant from vessels are starving and dying. In the model, these populations of cells were simplified into three different compartments (P, I, and H) that have different levels of proliferation, hypoxia, cell death, and radiosensitivity. Note that uniform levels of glucose and O2 were assumed for each compartment.
