Modeling the Relationship between Fluorodeoxyglucose Uptake and Tumor Radioresistance as a Function of the Tumor Microenvironment
Figure 2
Assumed FDG uptake patterns in each compartment. We use straight lines to emphasize that uptake probably varies across compartments, even though this variation is simplified in the model. The FDG uptake patterns were assumed to be (a) proportional to the total number of viable cells (pattern I), (b) associated mainly with proliferation with a minor contribution from intermediate hypoxic cells (pattern II), (c) associated mainly with intermediate hypoxia with a minor contribution from proliferating cells (pattern III), and (d) associated mainly with intermediate hypoxic cells with minor contributions from proliferating and extremely hypoxic/dying cells (pattern IV). Note that the sizes of the three compartments are variable depending on the microenvironmental conditions, although they are shown with the same size in the figure.
