First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene

Figure 5

GalNAc-T1 protein-protein interactions with 09 partners. One colour is given to each type of evidence in the predicted functional links (edges) among eight coloured lines. (a) From experimental basis (with score 0.925), only MUC1 is observed for interaction with GalNAc-T1. From text-mining data, GalNAc-T1 interactions are observed for GBGT1, CHPF, ST6GALNAC1, B4GALNT1, and MUC1 proteins with 0.970, 0.968, 0.952, 0.926, and 0.925 scores, respectively. The remaining interactions with C1GALT1C1, CIGALT1, GCNT1, and B3GNT6 proteins are simulated with STRING score ranging from 0.900 to 0.899. (b) Strong association pattern (thick blue lines) of GalNAc-T1 is predicted for GBGT1, CHPF, ST6GALNAC1, B4GALNT1, MUC1, C1GALT1C1, C1GALT1, GCNT1, B3GNT6, and ZNF146 partners with high confidence. For ST6GALNAC1-GBGT1, ST6GALNAC1-MUC1, GCNT1-CHPF, B4GALNT1-GCNT1, CHPF-C1GALT1C1, and GALNT1-ZNF146 pairs, weak associations are examined in the form of thin blue lines.