First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene

Table 1

List of nsSNPs with rs IDs found to be functionally significant by SIFT Tool.

rs IDs	Allele change	Amino acid change	SIFT score	SIFT prediction	Median
rs143502430	c.13G>A	A5T	0.55	TOLERATED	2.95
rs141224997	c.58T>G	L20V	1	TOLERATED	2.66
rs138822379	c.73C>G	L25V	0.07	TOLERATED	2.67
rs199595808	c.137A>G	D46G	0.3	TOLERATED	2.51
rs72964406	c.161C>T	P54L	0.28	TOLERATED	2.51
rs139185162	c.213T>G	D71E	1	TOLERATED	2.38
rs150799030	c.211G>C	D71H	0.07	TOLERATED	2.38
rs113616262	c.427T>C	S143P	0	DAMAGING	2.37
rs201338228	c.646G>A	V216M	0.14	TOLERATED	2.37
rs199977475	c.773G>T	G258V	0.04	DAMAGING	2.37
rs144282744	c.1135A>C	N379H	0.1	TOLERATED	2.37
rs146565032	c.1150A>G	I384V	0.52	TOLERATED	2.38
rs142387342	c.1202G>A	G401D	0.34	TOLERATED	2.37
rs34304568	c.1240T>C	Y414D	0	DAMAGING	2.37
rs151329739	c.1318A>C	N440H	0.08	TOLERATED	2.37
rs142110831	c.1528C>A	P510T	0.16	TOLERATED	2.37
rs145884536	c.1622A>G	N541S	0.45	TOLERATED	2.38
rs200444543	c.1657G>A	V553I	0.39	TOLERATED	2.66

SIFT score ≤ 0.05: damaging.