Research Article
First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene
Table 6
Ligand binding sites for wild type and mutant forms (S143P, G258V, and Y414D).
| Wild type | S143P | G258V | Y414D |
| Asn82 | Asn82 | Asn82 | Asn82 | Phe84 | Val123 | Phe84 | Phe84 | Val123 | Phe124 | Val123 | Val123 | Phe124 | His125 | Phe124 | Phe124 | His125 | Asn126 | His125 | His125 | Asn126 | Glu127 | Asn126 | Asn126 | Glu127 | Ala128 | Glu127 | Glu127 | Thr131 | Lau132 | Asp156 | Asp156 | Asp156 | Asp156 | Gly188 | Leu189 | Gly188 | Leu189 | Leu189 | Asp209 | Leu189 | Asp209 | Asp209 | Ala210 | Arg193 | Ala210 | Ala210 | His211 | Asp209 | His211 | His211 | Ile315 | Ala210 | Ile315 | Ile315 | Trp316 | His211 | Trp316 | Trp316 | His344 | Ile315 | Arg347 | His344 | Val345 | Trp316 | Thr350 | Val345 | Phe346 | His344 | Pro351 | Phe346 | Arg347 | Val345 | — | Arg347 | Lys348 | Phe346 | — | Lys348 | Ala349 | — | — | Ala349 | Thr350 | — | — | Thr350 | Pro351 | — | — | Pro351 | Tyr352 |
|
|