First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene

Table 6

Ligand binding sites for wild type and mutant forms (S143P, G258V, and Y414D).

Wild type	S143P	G258V	Y414D
Asn82	Asn82	Asn82	Asn82
Phe84	Val123	Phe84	Phe84
Val123	Phe124	Val123	Val123
Phe124	His125	Phe124	Phe124
His125	Asn126	His125	His125
Asn126	Glu127	Asn126	Asn126
Glu127	Ala128	Glu127	Glu127
Thr131	Lau132	Asp156	Asp156
Asp156	Asp156	Gly188	Leu189
Gly188	Leu189	Leu189	Asp209
Leu189	Asp209	Asp209	Ala210
Arg193	Ala210	Ala210	His211
Asp209	His211	His211	Ile315
Ala210	Ile315	Ile315	Trp316
His211	Trp316	Trp316	His344
Ile315	Arg347	His344	Val345
Trp316	Thr350	Val345	Phe346
His344	Pro351	Phe346	Arg347
Val345	—	Arg347	Lys348
Phe346	—	Lys348	Ala349
—	—	Ala349	Thr350
—	—	Thr350	Pro351
—	—	Pro351	Tyr352