Comparison of Two Methods Forecasting Binding Rate of Plasma Protein

Table 2

Experimental and calculated BRPP based on HA and SVM.

No.	Compd.	BRPP/(%)	HA	Residual	SVM	Residual
1^a	Acebutolol	26.0	35.9	9.9	40.0	14.0
2	Alprenolol	85.0	61.5	−23.5	72.9	−12.1
3	Amantadine	67.0	58.6	−8.4	61.9	−5.1
4	Amiodarone	100.0	110.9	10.9	100.3	0.3
5	Amitriptyline	94.8	100.1	5.3	90.1	−4.7
6^a	Aspirin	49.0	56.1	7.1	45.0	−4.0
7	Betamethasone	64.0	62.9	−1.1	61.0	−3.0
8	Bumetanide	99.0	92.6	−6.4	94.0	−5.0
9	Caffeine	36.0	28.0	−8.0	30.9	−5.1
10	Cefalexin	14.0	41.6	27.6	41.0	27.0
11^a	Chloroquine	61.0	67.7	6.7	75.6	14.6
12	Chlorthalidone	75.0	76.8	1.8	80.0	5.0
13	Cimetidine	19.0	17.2	−1.8	19.4	0.4
14	Ciprofloxacin	40.0	40.6	0.6	43.4	3.4
15	Diphenhydramine	78.0	83.2	5.2	83.9	5.9
16^a	Furosemide	98.8	85.8	−13.0	95.5	−3.3
17	Glibenclamide	99.0	114.0	15.0	95.1	−3.9
18	Haloperidol	92.0	91.3	−0.7	95.7	3.7
19	Lidocaine	70.0	60.6	−9.4	75.1	5.1
20	Methadone	89.0	94.3	5.3	94.0	5.0
21^a	Methotrexate	34.0	47.3	13.3	53.4	19.4
22	Metoclopramide	40.0	37.4	−2.6	44.3	4.3
23	Metronidazole	10.0	16.1	6.1	15.0	5.0
24	Nifedipine	96.0	91.0	−5.0	96.6	0.6
25	Phenobarbital	51.0	60.4	9.4	46.2	−4.8
26^a	Pindoioi	51.0	53.6	2.6	69.0	18.0
27	Prednisone	75.0	58.0	−17.0	69.9	−5.1
28	Quinidine	87.0	93.8	6.8	100.0	13.0
29	Ranitidine	15.0	15.7	0.7	15.6	0.6
30	Sulfadiazine	54.0	65.6	11.6	59.1	5.1
31^a	Sulfamethoxazole	62.0	56.4	−5.6	48.1	−13.9
32	Terbutaline	20.0	39.2	19.2	25.1	5.1
33	Timolol	60.0	44.6	−15.4	65.1	5.1
34	Triamterene	61.0	58.9	−2.1	66.1	5.1
35	Amikacin	4.0	−12.4	−16.4	5.4	1.4
36^a	Carbamazepine	74.0	72.2	−1.8	81.8	7.8
37	Carbenicillin	50.0	63.9	13.9	55.0	5.0
38	Cefamandole	74.0	78.7	4.7	76.1	2.1
39	Cefazolin	89.0	72.4	−16.6	83.9	−5.1
40	Cefotaxime	36.0	37.1	1.1	33.6	−2.4
41^a	Cefuroxime	33.0	52.6	19.6	53.4	20.4
42	Chloramphenicol	53.0	37.7	−15.3	47.9	−5.1
43	Chlorothiazide	94.6	83.2	−11.4	89.5	−5.1
44	Clonazepam	86.0	83.1	−2.9	80.9	−5.1
45	Cocaine	91.0	82.2	−8.8	85.9	−5.1
46^a	Dapsone	73.0	69.0	−4.0	66.6	−6.4
47	Dexamethasone	68.0	78.9	10.9	73.1	5.1
48	Diazepam	98.7	88.7	−10.0	93.6	−5.1
49	Ethinylestradiol	98.0	86.2	−11.8	92.9	−5.1
50	Famotidine	17.0	16.2	−0.8	11.9	−5.1
51^a	Fentanyl	84.0	85.8	1.8	90.2	6.2
52	Flecainide	61.0	80.6	19.6	66.0	5.0
53	Hydrochlorothiazide	58.0	57.6	−0.4	63.0	5.0
54	Imipramine	90.1	93.6	3.5	85.0	−5.1
55	Isoniazid	0.0	17.4	17.4	5.1	5.1
56^a	Isosorbide-5-mononitrate	0.0	10.7	10.7	−11.8	−11.8
57	Ketoconazole	99.0	90.4	−8.6	104.1	5.1
58	Lovastatin	95.0	101.3	6.3	100.0	5.0
59	Mexiletine	63.0	66.3	3.3	68.1	5.1
60	Nitrazepam	87.0	97.1	10.1	94.6	7.6
61^a	Norethisterone	80.0	76.1	−3.9	88.3	8.3
62	Omeprazole	95.0	89.9	−5.1	92.6	−2.4
63	Pethidine	58.0	72.0	14.0	76.3	18.3
64	Phenylbutazone	96.1	104.5	8.4	101.2	5.1
65	Propafenone	97.0	79.6	−17.4	91.0	−6.0
66^a	Propranolol	87.0	83.4	−3.6	90.3	3.3
67	Pyrimethamine	87.0	69.2	−17.8	79.8	−7.2
68	Thiopental	85.0	76.8	−8.2	79.9	−5.1
69	Ticarcillin	65.0	50.7	−14.3	59.9	−5.1
70	Warfarin	99.0	88.0	−11.0	94.0	−5.0

atest set.