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Computational and Mathematical Methods in Medicine
Volume 2014, Article ID 959753, 15 pages
Research Article

ADLD: A Novel Graphical Representation of Protein Sequences and Its Application

Lei Wang,1,2 Hui Peng,1,2 and Jinhua Zheng1,2

1Key Laboratory of Intelligent Computing & Information Processing, Ministry of Education, Xiangtan University, Xiangtan 411105, China
2College of Information Engineering, Xiangtan University, Xiangtan 411105, China

Received 14 August 2014; Accepted 25 September 2014; Published 30 October 2014

Academic Editor: Qi Dai

Copyright © 2014 Lei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To facilitate the intuitional analysis of protein sequences, a novel graphical representation of protein sequences called ADLD (Alignment Diagonal Line Diagram) is introduced in this paper first, and then a new ADLD based method is proposed and utilized to analyze the similarity/dissimilarity of protein sequences. Comparing with existing methods, our ADLD based method is proved to be effective in the similarity/dissimilarity analysis of protein sequences and have the merits of good intuition, visuality, and simplicity. The examinations of the similarities/dissimilarities for both the 16 different ND5 proteins and the 29 different spike proteins illustrate the utility of our ADLD based approach.