ADLD: A Novel Graphical Representation of Protein Sequences and Its Application

<div>(a) The ASD of the <i><i>β</i></i>-globin protein sequence pair (chimpanzee, human) with <svg height="12.7195pt" id="M159" style="vertical-align:-2.6064pt" version="1.1" viewbox="-0.0498162 -10.1131 34.7996 12.7195" width="34.7996pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M425 682C425 693 422 699 407 699C369 699 308 677 260 646C213 651 191 674 191 701C191 715 195 726 200 734L183 740C153 730 118 709 118 681C118 644 163 619 218 615C168 582 115 534 115 463C115 418 147 382 180 369C102 329 23 261 23 163C23 74 74 38 158 14C183 7 201 2 221 -2C279 -15 290 -33 290 -58C290 -94 251 -145 230 -169L252 -189C280 -171 367 -103 367 -25C367 20 333 51 266 68C245 73 218 80 191 89C139 106 107 135 107 192C107 261 161 329 221 355C248 350 281 347 314 347C330 347 370 388 370 406C370 418 366 422 352 422C321 422 280 413 255 407C218 413 192 448 192 493C192 544 229 588 266 610C309 610 354 615 376 623C397 631 425 651 425 682Z" id="g113-236"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="448" vert-adv-y="448"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,9.856,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,21.594,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,28.097,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z" id="g113-51"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>; (b) the ASD of the <i><i>β</i></i>-globin protein sequence pair (human, gorilla) with <svg height="12.7195pt" id="M160" style="vertical-align:-2.6064pt" version="1.1" viewbox="-0.0498162 -10.1131 34.7996 12.7195" width="34.7996pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M425 682C425 693 422 699 407 699C369 699 308 677 260 646C213 651 191 674 191 701C191 715 195 726 200 734L183 740C153 730 118 709 118 681C118 644 163 619 218 615C168 582 115 534 115 463C115 418 147 382 180 369C102 329 23 261 23 163C23 74 74 38 158 14C183 7 201 2 221 -2C279 -15 290 -33 290 -58C290 -94 251 -145 230 -169L252 -189C280 -171 367 -103 367 -25C367 20 333 51 266 68C245 73 218 80 191 89C139 106 107 135 107 192C107 261 161 329 221 355C248 350 281 347 314 347C330 347 370 388 370 406C370 418 366 422 352 422C321 422 280 413 255 407C218 413 192 448 192 493C192 544 229 588 266 610C309 610 354 615 376 623C397 631 425 651 425 682Z" id="g113-236"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="448" vert-adv-y="448"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,9.856,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,21.594,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,28.097,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 603 429 609L423 641C382 634 335 622 295 608C189 570 37 457 37 238C37 84 125 -12 242 -12C362 -12 447 89 447 209C447 311 374 393 267 393C247 393 226 386 204 376L137 343ZM227 337C318 337 361 256 361 173C361 105 336 22 258 22C176 22 126 120 126 240C126 266 127 291 132 310C155 323 189 337 227 337Z" id="g113-55"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>.</div>

Computational and Mathematical Methods in Medicine

fig1

Figure 1

Figure 1: ADLD: A Novel Graphical Representation of Protein Sequences and Its Application 