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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 124630, 12 pages
Research Article

Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases

1School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China
2Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, 1278 Ke Yuan Road, Shanghai 201203, China

Received 25 March 2015; Accepted 12 May 2015

Academic Editor: Lin Lu

Copyright © 2015 Bo Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table S1: The proteins and their sites of exact matched nsSNVs on each type of PTM. The proteins were shown with their UniProt Accession number.

Supplementary Table S2: The information of damaged PTM sites associated diseases annotated by SwissVar. For each type of PTM, the information of associated diseases for the exact matched and around matched PTM sites were given. The alterations between the modified amino acids of one type of PTM marked in red.

Supplementary Table S3: Enrichment results of keywords and GO. Both exact matched and ±2 matched results were shown. Inherited diseases were marked in yellow and cancers were marked in green.

Supplementary Table S4: Pathway analysis based on IPA. The results were boxed for each type of PTM, and the analysis were performed for both inherited diseases and cancers. P value and the ratio calculated based on IPA were shown.

Supplementary Table S5: Summary of biomarker candidates. The biomarker candidates were chosen based on information from IPA and details about them were shown.

  1. Supplementary Materials