Research Article
The Direct Assignment Option as a Modular Design Component: An Example for the Setting of Two Predefined Subgroups
Table 1
Options available at interim analysis (IA) in a 2-subgroup direct assignment design with 1 IA (DAD-1) versus a 2-subgroup balanced randomized design with 1 IA (BRD-1). The decisions are independently made in each subgroup at the time of IA. Some cells in the BRD-1 table are intentionally left blank, to highlight the missing option of direct assignment in this design. The options in bold are those that are available only in the design with direct assignment option.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||