Monte Carlo Calculation of Radioimmunotherapy with ⁹⁰Y-, ¹⁷⁷Lu-, ¹³¹I-, ¹²⁴I-, and ¹⁸⁸Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts

Table 4

Comparison of the total absorbed dose (), absorbed doses in the centre (), and absorbed doses at the surface () or surrounding the tumour (), in Gy, when ⁹⁰Y, ¹⁷⁷Lu, ¹³¹I, ¹²⁴I, and ¹⁸⁸Re are separately linked to antibodies distributed uniformly, linearly, and exponentially inside a 1.0 cm radius spherical tumour. Two different biological half-lives of 2 and 6 days are considered here.

Rad.	Dist.	[kBq]	[Gy]	Absorbed dose [Gy]
				= 2 days			= 6 days
				^90Y	Uni.	684.13	3.84	22.2	29.8	11.7	35.8	48.1	18.9
Lin.	3.84	21.6	14.5		13.2		34.9	23.5	21.3
Exp.	3.87	18.9	0.78		20.8		30.6	1.26	33.5
^131I	Uni.	228.29	0.60	2.67	3.06	0.97	5.73	6.55	2.09
	Lin.		0.60	2.66	1.23	1.13	5.71	2.65	2.42
	Exp.		0.60	2.61	0.31	2.43	5.60	0.67	5.20
^124I	Uni.	436.97	1.35	5.14	6.36	3.02	9.36	11.58	5.51
	Lin.		1.35	5.05	3.30	3.35	9.19	6.01	6.10
	Exp.		1.35	4.56	1.11	5.08	8.31	2.02	9.25
^177Lu	Uni.	222.32	0.36	2.07	2.25	0.53	4.26	4.63	1.09
	Lin.		0.36	2.07	0.75	0.65	4.26	1.53	1.34
	Exp.		0.36	2.06	0.03	1.73	4.24	0.05	3.55
^188Re	Uni.	2609.61	4.83	32.0	40.9	16.2	38.7	49.5	19.6
	Lin.		4.83	31.3	19.3	18.4	37.9	23.3	22.2
	Exp.		4.86	27.9	0.54	31.0	33.8	0.65	37.5

Computed dose error is estimated to 5% (1 SD).