Monte Carlo Calculation of Radioimmunotherapy with ⁹⁰Y-, ¹⁷⁷Lu-, ¹³¹I-, ¹²⁴I-, and ¹⁸⁸Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts

Table 6

Total absorbed dose (), absorbed doses at the surface (), and absorbed doses in the centre () or surrounding the tumour (), in Gy, required to obtain a maximum TCP of 100% when nanoobjects containing ⁹⁰Y, ¹⁷⁷Lu, and ¹⁸⁸Re are coupled with antibodies having a of 6 days and distributed uniformly, linearly, and exponentially inside a 1.0 cm radius spherical tumour. : number of radioactive atoms per nanoobjects required for TCP = 100%.

Rad.	Dist.	[kBq]			Dose
			Direct uptake	2 days of uptake	[Gy]	[Gy]	[Gy]	[Gy]
^90Y	Uni.	1850	3	5	106	142	56	11
	Lin.	1850	3	4	92	62	56	10
	Exp.	29600	43	73	1324	54	1450	167
^131I	Uni.	6290	27	33	157	180	57	16
	Lin.	5550	24	28	135	63	57	14
	Exp.	19240	85	101	474	56	440	51
^124I	Uni.	4440	10	14	96	119	57	14
	Lin.	4070	9	13	86	56	57	13
	Exp.	11470	26	36	216	52	240	35
^177Lu	Uni.	14430	52	65	224	243	57	19
	Lin.	11470	43	52	182	65	57	16
	Exp.	271210	996	1224	4220	53	3539	362
^188Re	Uni.	6660	3	19	101	129	51	13
	Lin.	5920	2	16	87	54	51	11
	Exp.	264920	102	726	3432	56	3805	494