Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation

<div>Tumor dynamics of 1000 virtual patients treated with RT or with RT plus PCV. (a) 1000 simulations of tumor size time course (MTD in mm versus time in years) for virtual LGG patients treated with RT. (b) 1000 simulations of tumor size time course for the same virtual LGG patients treated with RT followed by 6 cycles of PCV. The black lines represent the 10th, 50th, and 90th percentiles of the population dynamics.</div>

Computational and Mathematical Methods in Medicine

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Figure 1: Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation 

Figure 1 | Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation 