Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation

Figure 2

Simulation of tumor dynamics for particular patients based on model parameter estimates. (a) Simulation of tumor size time course (solid thick line) for a particular patient (patient 2 from our previous analysis [9]), characterized by the following set of parameters: mm, mm,  mo⁻¹,  mo⁻¹,  mo⁻¹,  mo⁻¹, , and KDE = 0.29 mo⁻¹ and treated with 6 cycles of PCV (grey area). The proliferative (solid thin line) and quiescent tissue (dashed line) dynamics are inferred from the MTD time course. (b) Simulation of tumor time course for a particular LGG patient (patient 3), characterized by the following set of parameters:  mm, mm,  mo⁻¹,  mo⁻¹,  mo⁻¹,  mo⁻¹, , and KDE = 0.32 mo⁻¹ and treated with 6 cycles of PCV. The prolonged response is shown to be mainly due to a durable inhibition of proliferative tissue after cessation of PCV treatment.

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