Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation

<div>Comparison between standard and modified protocols for particular patients. (a, b) Predicted percentage of proliferative tissue—the main target of PCV chemotherapy—for patient 2, according to the time of delivery of PCV cycles indicated by the vertical lines, under the standard protocol (a) and under a modified protocol with a prolonged interval between cycles (b, solid line). (c, d) Predicted percentage of proliferative tissue for patient 3, under the standard PCV protocol (c) and under a modified protocol with a prolonged interval between cycles (d, solid line).</div>

Computational and Mathematical Methods in Medicine

fig3

Figure 3

Figure 3: Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation 

Figure 3 | Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation 