Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation

Figure 4

Comparison between different therapeutic protocols for the virtual populations. (a) Kaplan-Meier curve of the time to tumor regrowth in virtual patients treated with the standard (thick dashed line) and the prolonged (thick solid line) PCV protocol. Thin line represents the Kaplan-Meier curve of the time to tumor regrowth for patients treated with an intermediate protocol: 6 PCV cycles every 3 months. (b) Kaplan-Meier curve of the time to tumor regrowth in virtual patients treated with RT plus standard PCV (dashed line) or RT plus modified PCV with a 6-month interval between cycles (solid line). Thin line represents the Kaplan-Meier curve of the time to tumor regrowth for patients treated with RT plus 6 cycles of PCV administered every 3 months.

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