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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 297903, 7 pages
Research Article

Increasing the Time Interval between PCV Chemotherapy Cycles as a Strategy to Improve Duration of Response in Low-Grade Gliomas: Results from a Model-Based Clinical Trial Simulation

1Inria, Project-Team NUMED, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69007 Lyon Cedex 07, France
2Hôpital Pierre Wertheimer, 59 boulevard Pinel, 69500 Bron, France

Received 20 July 2015; Revised 20 November 2015; Accepted 29 November 2015

Academic Editor: Issam El Naqa

Copyright © 2015 Pauline Mazzocco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary material provides a description of the model used in this study, with its schematic representation and mathematical equations. This model was analyzed through a population approach, using mixed-effects modeling. Model parameters were estimated using the full time-course of tumor size in 21 patients treated with PCV. The estimates are reported in the Supplementary material.

  1. Supplementary Material