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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 395826, 9 pages
Review Article

Genetic Consequences of Antiviral Therapy on HIV-1

1Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal
2Centre for Molecular Biology “Severo Ochoa”, Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain

Received 22 February 2015; Revised 26 May 2015; Accepted 27 May 2015

Academic Editor: Qi Dai

Copyright © 2015 Miguel Arenas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1. Nucleotide diversity variation.

Figure S2. Histogram on the distribution of the significant nonsynonymous substitutions (95% CI), induced by the studied PIs, along the PR coding gene.

Table S1. Estimates of overall mean distance with MEGA.

Table S2. Estimates of nucleotide genetic diversity.

Table S3. Estimates of molecular adaptation with Hyphy.

Table S4. Number and position of positively selected sites and negatively selected sites.

  1. Supplementary Materials