Structural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2

<div>Initial structure of WT protein with DNA (PDB ID: 3C2I). The two Arg residues (R133 and R111) are shown in yellow. The two methylated Cyt residues of DNA are shown in green. The 9 regions of protein are colored differently and sequence breakdown with structured regions is shown at the middle panel. The hydrogen bonding between R133 and R111 and DNA is shown (magenta colored lines in circles) at the bottom image.</div>

Computational and Mathematical Methods in Medicine

fig1

Figure 1

Figure 1: Structural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2 