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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 761435, 7 pages
Research Article

Mortality Prediction Model of Septic Shock Patients Based on Routinely Recorded Data

Department of Electronics, Information and Bioengineering, University Politecnico of Milan, Piazza Leonardo da Vinci 32, 20133 Milan, Italy

Received 31 July 2015; Revised 18 September 2015; Accepted 29 September 2015

Academic Editor: Dingchang Zheng

Copyright © 2015 Marta Carrara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We studied the problem of mortality prediction in two datasets, the first composed of 23 septic shock patients and the second composed of 73 septic subjects selected from the public database MIMIC-II. For each patient we derived hemodynamic variables, laboratory results, and clinical information of the first 48 hours after shock onset and we performed univariate and multivariate analyses to predict mortality in the following 7 days. The results show interesting features that individually identify significant differences between survivors and nonsurvivors and features which gain importance only when considered together with the others in a multivariate regression model. This preliminary study on two small septic shock populations represents a novel contribution towards new personalized models for an integration of multiparameter patient information to improve critical care management of shock patients.