Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes

Figure 2

Cryopyrin inflammasome formation steps. (1) With DAMP or PAMP, inflammasome formation process is triggered. (2) A conformational change occurs in Cryopyrin protein due to the trigger. (3) Interaction between PYDs of ASC and Cryopyrin protein becomes possible after the conformational change. (4) CARD of ASC and procaspase 1 interact. (5) Cardinal brings another procaspase 1 to the system. (6) Induced proximity mediated autocatalysis results in the activation of Caspase 1. (7) Caspase 1 bioactivates IL-1β by cleavage.