The Structural Characterization of Tumor Fusion Genes and Proteins

Figure 2

Nucleotide combinations of human genes and breakpoint in fusion genes. (a) Nucleotide preference at each site near the breakpoint in the partner genes. (b) Nucleotide preference at each site near the breakpoint in the fusion genes. ((c)-(d)) Frequency of dinucleotide occurrence at the breakpoint of partner genes (c) and fusion genes (d) compared to background human genes. (The blue line is the nucleotide combination of human genes, the occurrence of the combinations is similar, yellow line is the nucleotide combination of the breakpoint in fusion genes, and the occurrence of the combinations is different statistically.) ((e)-(f)) Sequence preference before the breakpoint in the partner genes (e) and fusion genes (f). The axis presents positions and , and the different colors represent different nucleotide at .

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