Modeling the Interaction between β-Amyloid Aggregates and Choline Acetyltransferase Activity and Its Relation with Cholinergic Dysfunction through Two-Enzyme/Two-Compartment Model

Figure 3

Possible competitive inhibition mechanisms for β-amyloid ([Aβ]) during pH-dependent ChAT synthesis of ACh (areas of inhibition are displayed in square brackets). The reaction route occurs in the vertical direction. is the active form of the enzyme; and are the protonated and deprotonated inactive forms. , , and are enzyme intermediate complexes. (a) β-amyloid competitively binds to active enzyme complex ; (b) β-amyloid competitively binds to enzyme intermediate .

(a)

(b)