Illustration of a tissue concentration-time curve (yellow) with respect to an arterial input function (AIF) (blue). The deconvolution of the tissue curve with removes the dependence on the AIF and produces the residue function (b). CBF is extracted at the maximum value reached at , while MTT is calculated as CBV/CBF, where CBV is determined as the area under the tissue curve (yellow). Because of the presence of arterial delays in stroke patients, the residue function is not always maximal at but might be maximal after a delay ().
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.