Computational and Mathematical Methods in Medicine

Research Article

The Role of Parvalbumin, Sarcoplasmatic Reticulum Calcium Pump Rate, Rates of Cross-Bridge Dynamics, and Ryanodine Receptor Calcium Current on Peripheral Muscle Fatigue: A Simulation Study

Table 1

Parameter groups.


Group	Parameter	Definition

1	61	SR Ca²⁺-pump uptake rate

2	89	Rate of cross-bridge attachment
	90	Rate of pre-power stroke cross-bridge detachment
	91	Forward rate of the power stroke
	92	Reverse rate of the power stroke
	93	Rate of post-power stroke cross-bridge detachment
	94	Rate of myoplasmic phosphate degradation

3	99	RyR Ca²⁺ current

4	71, 72	Binding and dissociation rate of Ca²⁺-parvalbumin
4	74, 75	Binding and dissociation rate of Mg²⁺-parvalbumin

	1	Membrane capacitance
	2	Ratio of t-tubule membrane area to sarcolemma membrane area
	8, 9	t-tubule diffusion time constant
	10	Fraction of fibre occupied by t-tubules
	11, 12	Interstitial space diffusion time constant
	13, 14	Resting K⁺ and Na⁺ current
	25, 28	Factors for slow inactivation Na⁺-gating
	38, 39, 40	Cl⁻, K⁺, and Na⁺ conductance in two compartment model
	41	Maximum IR conductance
	48	Maximum Na⁺-K⁺ pump activity
	63	SR Ca²⁺ leak constant
	68	Binding rate of Ca²⁺-troponin

Group 1 contains the SR Ca²⁺-pump uptake rate parameter that is associated with force reduction; Group 2 contains the parameters associated with the cross-bridge cycle; Group 3 contains the parameter associated with rate of Ca²⁺ release from the SR; Group 4 describes parameters associated with the binding to and the dissociation from parvalbumin; Group contains the remaining parameters that influence the muscle unit type behaviour within the model.