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Computational and Mathematical Methods in Medicine
Volume 2016, Article ID 3262813, 12 pages
Research Article

Circular Helix-Like Curve: An Effective Tool of Biological Sequence Analysis and Comparison

College of Science, Yanshan University, Qinhuangdao 066004, China

Received 18 February 2016; Accepted 19 April 2016

Academic Editor: Nadia A. Chuzhanova

Copyright © 2016 Yushuang Li and Wenli Xiao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper constructed a novel injection from a DNA sequence to a 3D graph, named circular helix-like curve (CHC). The presented graphical representation is available for visualizing characterizations of a single DNA sequence and identifying similarities and differences among several DNAs. A 12-dimensional vector extracted from CHC, as a numerical characterization of CHC, was applied to analyze phylogenetic relationships of 11 species, 74 ribosomal RNAs, 48 Hepatitis E viruses, and 18 eutherian mammals, respectively. Successful experiments illustrated that CHC is an effective tool of biological sequence analysis and comparison.