Computational and Mathematical Methods in Medicine / 2016 / Article / Fig 1

Research Article

A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2

Figure 1

A cell cycle model (compartments , , and ) is extended to include spheroid dynamics, including quiescent cells () and the necrotic core (). Rates are indicated near arrows. Quantities , , and are dependent on the state of the system. If parameters are chosen so that and , the resulting model simulates monolayer growth.

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