A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ₂

Figure 1

A cell cycle model (compartments , , and ) is extended to include spheroid dynamics, including quiescent cells () and the necrotic core (). Rates are indicated near arrows. Quantities , , and are dependent on the state of the system. If parameters are chosen so that and , the resulting model simulates monolayer growth.