Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study

Figure 2

(a) EADs were induced when 1 μM ISO was applied and was blocked by 85%. In (b), EADs disappeared when blockage was reduced to 77%. Cycle length was set 2000 ms and CaMKII phosphorylation level to all targets was kept control (CaMK₀ = 0.05).

(a)

(b)