Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study

Table 1

Current increment and EADs occurrence when different targets were phosphorylated by CaMKII independently.

Cycle length (ms)	blockage level (%)	CaMKII target (CaMK0 = 0.12)	Target current variation	Deactivation time (ms)	EADs
2000	85		Decreased by 24%; (from 0.25 to 0.19 µA/µF)	1297 versus 761 ms	Alternated
			Increased by 4.2%; (from 1.67 to 1.74 µA/µF)		No
			Increased by 6.5%; (from 0.62 to 0.66 µA/µF)		No
			Increased by 8.1%; (from 0.37 to 0.40 µA/µF)		No
			Increased by 3.2%; (from 0.95 to 0.98 µA/µF)		No