Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain

Algorithm 2

Generating for -point mutations.

(1) procedure ESTIMATEDELTAE(, , , )

(2)      List(“ARNDCQEGHILKMFPSTWYV")

(3)     Table     //for each element in Results

(4)     

(5)     Tuples

(6)     for () tuples in   do

(7)    for   in   do

(8)        for   in   do

(9)       

(10)       for   in   do

(11)            mutate(, , )

(12)           

(13)           

(14)       end for

(15)       

(16)        end for

(17)     end for

(18)     end for

(19)      //Sort on second element ascending

(20)     return  

(21) end procedure