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Computational and Mathematical Methods in Medicine
Volume 2016, Article ID 6740956, 12 pages
Research Article

A Fusion-Based Approach for Breast Ultrasound Image Classification Using Multiple-ROI Texture and Morphological Analyses

1Department of Computer Engineering, German Jordanian University, Amman, Jordan
2Jordan University Hospital, The University of Jordan, Amman, Jordan

Received 5 August 2016; Revised 31 October 2016; Accepted 15 November 2016

Academic Editor: Kenji Suzuki

Copyright © 2016 Mohammad I. Daoud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ultrasound imaging is commonly used for breast cancer diagnosis, but accurate interpretation of breast ultrasound (BUS) images is often challenging and operator-dependent. Computer-aided diagnosis (CAD) systems can be employed to provide the radiologists with a second opinion to improve the diagnosis accuracy. In this study, a new CAD system is developed to enable accurate BUS image classification. In particular, an improved texture analysis is introduced, in which the tumor is divided into a set of nonoverlapping regions of interest (ROIs). Each ROI is analyzed using gray-level cooccurrence matrix features and a support vector machine classifier to estimate its tumor class indicator. The tumor class indicators of all ROIs are combined using a voting mechanism to estimate the tumor class. In addition, morphological analysis is employed to classify the tumor. A probabilistic approach is used to fuse the classification results of the multiple-ROI texture analysis and morphological analysis. The proposed approach is applied to classify 110 BUS images that include 64 benign and 46 malignant tumors. The accuracy, specificity, and sensitivity obtained using the proposed approach are 98.2%, 98.4%, and 97.8%, respectively. These results demonstrate that the proposed approach can effectively be used to differentiate benign and malignant tumors.