Spectral Analysis of Dynamic PET Studies: A Review of 20 Years of Method Developments and Applications

Table 1

Overview of Spectral Analysis methods.

Full Name	Exponential Spectral Analysis	Rank-shaping spectral analysis	Spectral analysis with iterative filter	Nonlinear spectral analysis
Description
Short name	ESA	RS	SAIF	NLSA
Type of tracer kinetics	Any	Reversible tracers only	Irreversible tracers only	Any
Main parameters of interest	/, ,		, ,	, ,
Required settings	Grid of components	Grid of components SNR	Grid of components Filter passband	None
Outputs
Data fit	✓	✓	✓	✓
Kinetic spectrum	✓	—	✓	✓
ROI analysis	✓	—	✓	✓
VOXEL analysis	—	✓	✓	—

: distribution volume; : trapping rate constant; : blood volume; : weighted average influx rate constant; SNR: signal-to-noise ratio.