Towards the Design of a Patient-Specific Virtual Tumour

Table 1

Model parameters.

Parameter	Unit	Value	Description	Reference
	mm^2⋅h^−1		Proteases diffusion coefficient	[17]
	h^−1	130	Proteases production rate by sprout	[17]
	h^−1	1.30	Proteases decay rate	[17]
	mm^2⋅h^−1		Tumour proteases diffusion coefficient	Adapted from [17]
	h^−1	3600	Proteases production rate by tumour cells	Adapted from [17]
	h^−1	0.21	Tumour proteases decay rate	Adapted from [17]
	mm^2⋅h^−1		Growth factor diffusion coefficient	[18]
	s^−1	0.0145	Growth factor production rate by quiescent cells	Estimated
	h^−1	0.65	Growth factor decay rate	[19]
	h^−1	1	Consumption rate of growth factor by endothelial cells	[19]
	h^−1	0.06	Max consumption of growth factor by endothelial cells	[19]
	mm^2⋅h^−1		Oxygen diffusion coefficient	[20]
	mm^−1⋅s^−1		Vessels permeability to oxygen	[21]
	s^−1	2.4	Oxygen consumption rate by normal cells	Based on [22]
	s^−1		Oxygen consumption rate by proliferative cells	Based on [21]
	s^−1		Oxygen consumption rate by quiescent cells	Based on [21]