Computational and Mathematical Methods in Medicine / 2016 / Article / Tab 1

Research Article

In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies

Table 1

Formulation of WT and mutated sodium channels (-p.R222Q and -p.I141V) in the presence or absence of 30 µM of E3G. The bold font corresponds to mutations effect and the bold-italic font to E3G effects.

TNNP/SANNBZ models, p.R222Q.TNNP/SANNBZ models, p.I141V.TNNP/SANNBZ models, TNNP/SANNB models,

WT, WT () = , WT ()
, WT () = , WT ()
WT () = , WT ()
, WT () = , WT ()
WT () = , WT ()
, WT () = , WT ()
, WT () = , WT ()
WT () = , WT ()
, WT () = , WT ()
WT () = , WT ()
100% of 100% of

WT + 30 µM E3G, WT () = , WT ()
, WT () = , WT ()
WT () = , WT ()
, WT () = , WT ( + 6)
WT () = , WT ()
, WT () = , WT ()
, WT () = , WT ()
WT () = , WT ()
, WT () = , WT ( + 6)
WT () = , WT ()
80% of 50% of

Mutants, p.I141V () = , WT , p.I141V () = , WT ()100% of 100% of
, p.I141V () = , WT (), p.I141V () = , WT
, p.I141V () = , WT (), p.I141V () = , WT ( + 7)
, p.I141V () = , WT ( + 6.2)
WT () = , WT ()
, p.I141V () = , WT ()
WT () = , WT ( + 7)

Mutants + 30 µM E3G, p.I141V () = , WT , p.I141V () = , WT 80% of 50% of
, p.I141V () = , WT (), p.I141V () = , WT
, p.I141V () = , WT (), p.I141V () = , WT ( + 7)
, p.I141V () = , WT ( + 6.2 + 6), p.I141V () = , WT ( + 6)
WT () = , WT ()WT () = , WT ( + 7)

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